March 2, 2016

Saralyn Mark, MD Feedback from TappMD Expert
Saralyn Mark, MD
Personalized Medicine
Personalized medicine will improve safety and efficacy of the drugs and radiation used to treat cancer. This enters the realm of precision medicine and predictive toxicology. Genomic profiling will change how healthcare is delivered.

Just like a massive iceberg jutting out of the ocean, many of cancer’s genetic underpinnings remain hidden under the surface, impossible to predict or map from above. The foreboding shadows and shapes that appear on CT scans and MRIs – and even in the field that doctors see when they zoom in to look at cancer cells under a high-powered microscope – are just the tip of the iceberg.

Penn Medicine’s new Center for Personalized Diagnostics, a joint initiative of the department of Pathology and Laboratory Medicine in the Perelman School of Medicine and the Abramson Cancer Center, is diving deeper into each patient’s tumor with next generation DNA sequencing. These specialized tests can refine patient diagnoses with greater precision than standard imaging tests and blood work, all with an aim to broaden treatment options and improve their efficacy. “We’re using the most advanced diagnostic methods to unlock cancer’s secrets,” says David B. Roth, MD, PhD, chairman of the department of Pathology and Laboratory Medicine. “A tumor’s genomic profile is the most critical piece of information for an oncologist to have when they’re deciding what therapy to recommend. The results of tests in the Center for Personalized Diagnostics reveal a genetic blueprint of each patient’s tumor that is as discrete and singular as a fingerprint.” The Center for Personalized Diagnostics unites top experts in genomic analysis, bioinformatics, and cancer genetics – who use the most sensitive data analysis tools available to identify the rarest of mutations – with oncologists who treat patients and design clinical trials to test new therapies. Together, their efforts will provide cancer patients with cutting-edge diagnostic and therapeutic options.

Read more at: http://medicalxpress.com/news/2013-04-individualized-genomic-tailored-cancer-treatment.html#jCp

 

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Saralyn Mark, MD

Saralyn Mark, MD, an endocrinologist, geriatrician and women's health specialist, was the first Senior Medical Advisor to the Office on Women's Health within the Department of Health and Human Services for 11 years and to the National Aeronautics and Space Administration (NASA). As Senior Medical Advisor, Dr. Mark was responsible for the development and analysis of initiatives and programs on emerging technologies, public health preparedness, physician workforce issues, sex and gender-based medicine and women's health on Earth and in Space.

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